RST SleepPractitioner wholesale

Built by an ER doctor for people who sleep at 9am.

After 14 years rotating between nights, days, and swing shifts, I built the sleep formula nothing on the shelf offered — one that targets circadian disruption, not just falling asleep.

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John-Ryan McAnnally, MD — Emergency Medicine
John-Ryan McAnnally, MD · Emergency Medicine
The problem your patients bring you

Shift workers aren't just tired — they're fighting their own biology.

Sleeping at 9am means falling asleep against a rising cortisol curve and a suppressed melatonin signal. Standard melatonin products address neither. That's why the nurses, medics, and plant workers on your table keep telling you they're exhausted no matter what they try.

The formula

Five mechanisms. One capsule pair.

Two capsules, taken 30–45 minutes before sleep — whatever hour that is.

IngredientDoseRationale
Glycine750 mgLowers core body temperature to initiate sleep onset — the signal daytime sleepers don't get naturally
Phosphatidylserine200 mgBlunts the elevated cortisol that keeps post-shift sleepers wired at 9am
Magnolia bark400 mgGABAergic — quiets the wind-down phase without next-shift grogginess
Apigenin100 mgSupports sleep latency and calm via GABA-A modulation
Melatonin (dual-release)immediate + extendedImmediate release for onset; extended release to hold sleep through daylight hours when endogenous melatonin is absent

This isn't a sedative stack. Each ingredient targets a specific mechanism of circadian disruption — temperature, cortisol, GABA tone, and the melatonin curve itself.

The evidence

You'll want to check the literature. So did I.

Every ingredient was chosen for a mechanism with peer-reviewed support — not because it tests well in marketing. Open any ingredient below for the studies. These are the papers I read before I put my own name on the label.

Glycine core-temperature drop that initiates sleep onset
  1. Yamadera et al. — Glycine ingestion improves subjective sleep quality, correlating with polysomnographic changes. Sleep and Biological Rhythms, 2007.
  2. Inagawa et al. — Subjective effects of glycine ingestion before bedtime on sleep quality. Sleep and Biological Rhythms, 2006.
  3. Bannai et al. — The effects of glycine on subjective daytime performance in partially sleep-restricted healthy volunteers. Frontiers in Neurology, 2012.
  4. Bannai & Kawai — New therapeutic strategy for amino acid medicine: glycine improves the quality of sleep. Journal of Pharmacological Sciences, 2012.
  5. Razak et al. — Multifarious beneficial effect of nonessential amino acid, glycine: a review. Oxidative Medicine and Cellular Longevity, 2017.
Phosphatidylserine blunts the cortisol / HPA-axis response to stress
  1. Hellhammer et al. — A soy-based phosphatidylserine/phosphatidic acid complex normalizes HPA-axis stress reactivity in chronically stressed men: randomized, placebo-controlled. Lipids in Health and Disease, 2014.
  2. Monteleone et al. — Effects of phosphatidylserine on the neuroendocrine response to physical stress in humans. Neuroendocrinology, 1990.
  3. Monteleone et al. — Blunting by chronic phosphatidylserine administration of the stress-induced activation of the HPA axis in healthy men. European Journal of Clinical Pharmacology, 1992.
  4. Starks et al. — The effects of phosphatidylserine on endocrine response to moderate-intensity exercise. Journal of the International Society of Sports Nutrition, 2008.
  5. Hellhammer et al. — Omega-3 fatty acids administered in phosphatidylserine improved certain aspects of high chronic stress in men. Nutrition Research, 2012.
Magnolia bark GABAergic wind-down without next-shift grogginess
  1. Chen et al. — Magnolol induces sleep via the benzodiazepine site of the GABA(A) receptor in mice. Neuropharmacology, 2012.
  2. Alexeev et al. — The natural products magnolol and honokiol are positive allosteric modulators of synaptic and extra-synaptic GABA(A) receptors. Neuropharmacology, 2012.
  3. Kuribara et al. — Honokiol, a putative anxiolytic from magnolia bark, has no diazepam-like side-effects in mice. Journal of Pharmacy and Pharmacology, 1999.
  4. Talbott et al. — Effect of Magnolia officinalis and Phellodendron amurense on cortisol and mood in moderately stressed subjects: randomized, placebo-controlled. Journal of the International Society of Sports Nutrition, 2013.
  5. Kalman et al. — Effect of a proprietary Magnolia/Phellodendron extract on stress levels in healthy women: pilot, double-blind, placebo-controlled trial. Nutrition Journal, 2008.
Apigenin calm and sleep latency via GABA-A modulation
  1. Avallone et al. — Pharmacological profile of apigenin, a flavonoid isolated from Matricaria chamomilla. Biochemical Pharmacology, 2000.
  2. Viola et al. — Apigenin, a component of Matricaria recutita flowers, is a central benzodiazepine-receptor ligand with anxiolytic effects. Planta Medica, 1995.
  3. Zanoli et al. — Anxiolytic flavonoid ligands of the central benzodiazepine receptor. Pharmacology Biochemistry and Behavior, 1997.
  4. Zick et al. — Standardized chamomile (apigenin-rich) extract for chronic primary insomnia: randomized placebo-controlled pilot. BMC Complementary and Alternative Medicine, 2011.
  5. Apigenin: a natural molecule at the intersection of sleep and aging. Frontiers in Nutrition, 2024.
Melatonin (dual-release) onset now, hold through daylight hours
  1. Lemoine et al. — Prolonged-release melatonin improves sleep quality and morning alertness in insomnia patients 55 and older, with no withdrawal effects. Journal of Sleep Research, 2007.
  2. Wade et al. — Nightly prolonged-release melatonin for 6 months in primary insomnia: randomized placebo-controlled trial. BMC Medicine, 2010.
  3. Sadeghniiat-Haghighi et al. — Efficacy and hypnotic effects of melatonin in shift-work nurses: double-blind, placebo-controlled crossover trial. Journal of Circadian Rhythms, 2008.
  4. The MIDNIGHT Trial — melatonin in doctors and nurses working nightshifts: feasible, safe, acceptable. Nature and Science of Sleep, 2020.
  5. The use of prolonged-release melatonin in circadian medicine: a systematic review. 2024.

Links open PubMed, PMC, or the publisher of record. RST Sleep is a dietary supplement; these studies describe the mechanisms and ingredients, and are not claims that the product diagnoses, treats, or cures any condition.

Why I'm writing you directly

I'm my own best customer. After a string of nights I don't switch back to days without it, and neither do the people I work with who've tried it. This isn't a brand reaching out to a buyer — it's one clinician telling another about something that actually helped.

Your patients who work shifts are already telling you they can't sleep. I'd rather you have something real to hand them than watch them cycle through the drugstore shelf. If it helps them the way it helped me, that's the whole point.

— John-Ryan McAnnally, MD · Emergency Medicine
The practice math

Margin on a visit that's already happening.

$39.50
Wholesale / bottle
$79
MSRP
$39.50
Your margin / bottle
Zero-risk start

The 60-Day Starter Case

Six bottles at wholesale. Put them on the front desk. If they haven't moved in 60 days, ship them back on me — full refund, no questions.